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The hydrophilic part consists ofpolyethylene glycols and glycerol ethoxylate. Aqueous Cremophor RH 40 solutions can be sterilized by heating to C. The tolerance of Cremophor RH 40 was checked by intravenous adminis-tration in rats over a period of four weeks.
Coke7 rated a book really liked it The Book of Light: Further addition of water then decreases the viscosity again. No teratogenicor embryotoxic effects were detected. Note The data submitted in this publication are based on our current knowledgeand experience. Home Documents Cremo Phor Rh Chemical nature Cremophor RH 40 lljudska a devolucij solubilizer and emulsifying agent obtainedby reacting 45 moles of ethylene oxide with 1 mole of hydrogenated castoroil.
If thefirst half of the water is added too quickly, the solution can become opal-escent.
Want to Read saving… Error rating book. For this reason, it is advisable to subjectpreparations containing Cremophor RH 40 to pharmacological and clinicaltests before they are released for general use. A feature of the solutionsthus obtained is their good stability. None of the animals displayed any symptomswhatever of poisoning. Thanks for telling us about the problem.
Use as emulsifier Cremophor RH 40 is eevolucija very suitable as an emulsifying agent. No such reactions have been observed after oral administration. Apr 12, The following substances serve asexamples: The fact that the solubilizer has very little taste and odour is an asset for suchapplications.
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If the containers are repeatedly opened, microorga-nisms may grow in the product, particularly if the equipment used is notsterile.
Thewater, also heated to 60 65 C, is added very slowly with thorough stir-ring into this mixture.
Just a moment while we sign you in to your Goodreads account. ToxicityAcute toxicity The following values for the average lethal dose LD 50 with a seven-dayfollow-up period were determined for Cremophor RH Post on Oct 5 views. Properties Cremophor RH 40 is a white to yellowish thin paste at 20 C.
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La casa dei fantasmi by Max Bunker. The HLBvalue devolucuja between 14 and Message Ljudsak books Block this user. Packaging Drums of 40 kg capacity. Storage The drums in which Cremophor RH 40 is stored should be kept tightlyclosed.
Teratogenicity This was investigated by the FDA guidelines for reproduction studies forsafety evaluation of drugs for human use Food and Drug Administration,Washington, January As a result of hydration, the solution thickens, withthe viscosity attaining a maximum after about half of the water has beenadded. Stability Pure Cremophor RH 40 is chemically very stable.
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