Evolución de la leucemia linfoblástica aguda en la edad pediátrica en 29 años ( )Outcome of acute lymphoblastic leukemia in the pediatric age group . La leucemia linfoblástica aguda (LLA) es el cáncer más común en los niños y está entre los más curables de las malignidades pediátricas. El análisis citogenético de las células blásticas en niños con leucemia linfoblástica aguda (LLA) ha permitido el reconocimiento de alteraciones cromosómicas.

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The relapse rate was not increased, if compared with non DS ALL patients; in this group the infections were the determinant factor for a lower survival.

The formation of trisomies and their parental origin in hyperdiploid chilhood acute lymphoblastic leukemia.

Leukemia ; Clinical and cytogenetic characteristics and treatment outcome: Down Syndrome, Drug Metabolism and Chromosome Current status of cytogenetic research in childhood acute lymphoblastic leukemia.

Blood, 79pp.

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J Clin Oncol, 14pp. Precocious aging of the immune system in Down syndrome: Outcome heterogeneity in chilhood high hyperdiploid acute lymphoblastic leukemia. Cancer, 40pp. Abnormal serum IgG subclass pattern in children with Down’s syndrome.

Alteraciones cromosómicas en la leucemia linfoblástica aguda | Anales de Pediatría

A mathematical model of in vivo methotreaxate accumulation in acute lymphoblastic leukemia. Blood, 76pp. Genes Chromosom Cancer, 9pp. Clinical data, immunophenotype, cytogenetics and treatment results were analyzed. J Clin Oncol, 12pp.


Estos pacientes pueden ser tratados con los protocolos actuales pero requieren un manejo precoz e intensivo de las infecciones. J Pediatr ; Immunologic, cytogenetic, and clinical characterization of childhood acute lymphoblastic leukemia with the t 1;9 q23;p13 or its derivative.

These patients can be treated with the current trials but they require a detailed infection care. Pediatr Hematol Oncol ; 9: Nonrandom involvement of the 12p12 breakpoint in chromosome abnormalities of childhood acute lymphoblastic leukemia. Ziemin-Van der Poel, N. Many of these chromosomal alterations are associated with specific cytomorphological and immunological types.

Leucemia linfoblástica aguda en pacientes portadores de síndrome de Down

Clinical characteristics and treatment outcome of children with acute lymphocytic leukemia and Down’s syndrome. There was no difference by age or gender, no patient presented LLA-T, t 9;22 o t 4; Hyperdiploid acute lymphoblastic leukemia in children.

Cytogenetic abnormalities in childhood acute lymphoblastic leukemia correlates with clinical features and treatmentoutcome. Si consideramos que las infecciones son la principal causa de mortalidad en los pacientes con SD en tratamiento por LLA, debemos implementar estrategias que logren disminuir estos eventos como: The linfoblastifa impact on patient management has been the finding that the cytogenetic result is an independent prognostic indicator.


Unifirm approch to risk classification and treatment assignment to children with acute lymphoblastic leukemia. Pediatr Clin North Am ; Epub Sep Most patients with ALL show karyotype abnormalities, either in chromosome number ploidy or as structural changes such as leucemmia, inversions, or deletions. Principles and practice of pediatric oncology 4 th Edition Philadelphia.

Oncogene, 7pp. The management of patients with leukemia: Blood, 68pp. Arch Dis Child ; Mol Cell Biol, 14pp.

Blood and Cancer ; This study focuses on the most important chromosomal abnormalities found in childhood ALL and their prognostic and therapeutic implications. Hospital Higueras Talcahuano, Drs: A Pediatric Oncology Group Study. Insights into the manifestations, outcomes, and mechanisms of leuke mogenesis in Down syndrome.

Factores de riesgo para la leucemia linfocítica aguda

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Collaborative study of karyotypes in childhood acute lymphoblastic leukemia. Continuing navigation will be considered as acceptance of this use.