LEI 11036 PDF

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Then we downloaded the relevant papers and further screened to identify potentially eligible studies.

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J Oral Pathol Med. However, ‘the best available evidence’ might not be always equal to ‘sufficient evidence’. Epidemiological studies showed that OSCC have been associated with high tobacco abuse and alcohol consumption [ 7 – 11 ]. The assessment was performed independently by two investigators and the inconformity was solved by a discussion, or consultation if necessary.

Kaohsiung J Med Sci. All data was independently reviewed and extracted from the included papers by two investigators. A star system is used to assess the quality of all selected studies. Glutathione S-transferase T1 gene deletion polymorphism and lung cancer risk in Chinese population: Searched results were in dependently screened by two authors according to the titles, abstracts and types of articles, and irrelevant papers were dropped out.

The simulation results show that our BTDGS is an energy effective, reliable, timely, and sojourn time adaptive data gathering scheme. Relevance of LIG4 gene polymorphisms with cancer susceptibility: And two studies were excluded as they were concerned of prognosis and only contained the cases, lacking of controls. Therefore, it is more reasonable to assess the association of gene polymorphisms with risks of OSCC, oral adenocarcinoma and other types, separately.


Finally, heterogeneity was existed, which might weaken the reliability of conclusions. The number of cases and controls in the papers included in this meta-analysis for varied from 31 to60 torespectively.

When all of the four models were performed sensitivity analysis, the estimates in these four models changed between lower CI limits and upper CI limits, suggesting the results in this meta-analysis were stable. The data of all four models indicated that there were not significant publication biases for all them. We established a database concerning of the information extracted from each included paper. However, the conclusions are inconsistent.

For instance, Singh, et al. J Exp Clin Cancer Res. The following characteristic were collected from each study, ethnicity, country, sample size, control source, matching contents, the Hardy-Weinberg Equilibrium HWEand genetic distribution of cases and controls.

When the data were not clear nor presented by the author in the publication, contacting them for further details were attempted. The details of allele comparing model were also shown lie the Table 2. People come from different places may share different genotypes, thus, applicability of the results are limited. Of the 13 studies included in this meta-analysis, eight studies were performed in Asians, 1103 in Caucasians, and one in mixed 110336.

As for the other three models homozygous model, dominant model and allele comparing modelthey failed to show obvious association between CYP1A1 IleVal polymorphism and OSCC risk, and the heterogeneities among studies were observed in them, respectively.

Null Glutathione S-transferase T1 and M1 genotypes and oral cancer susceptibility in China and India–a meta-analysis.

Bucharest is 34% cheaper than Tripoli. Dec Cost of Living.

Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to oral cavity cancer. The search process lsi designed to find primarily all relevant articles and the search strategies were listed as follows: After the subgroup analyses by ethnicity, source of control, HWE, the heterogeneities were not removed, indicating that other factors, such as age, gender, country, lifestyle, social status, smoking and alcohol habits might also yield to heterogeneities. Differences between reviewers were solved by discussion, or through consultation if necessary.


If a consensus could not be attained, another author was invited to solve the dispute and then a final result was made by the majority of the votes.

And future studies focusing on CYP1A1 IleVal polymorphism containing large sample lie and well-designed criteria are necessary to make the conclusions more credible. Association of glutathione S-transferase P1 gene polymorphism with the histological types of lung cancer: Despite advances in treatment for OSCC, the 5-year survival rate remains undesirable [ 4 – 6 ].

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Besides, six papers were excluded because of failing to provide sufficient data. CYP1A1 genotypes and haplotypes and risk of oral cancer: Users should refer to the original published version of the material for the full abstract. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis.

Oral cancer prevention 1136 control–the approach of the World Health Organization. Global reach, higher impact. Based on this issue, we applied the TSA to estimate the power of the current conclusions [ 32 – 34 ].

Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses.