JMJC-DOMAIN-CONTAINING PROTEINS AND HISTONE DEMETHYLATION PDF

Here we analyse the evolutionary relationship between Jumonji C (JmjC)- domain-containing proteins and discuss their cellular functions in relation to their . Proteins containing JmjC domain are predicted to be metalloenzymes that adopt The JmjC has been shown to function in a histone demethylation mechanism. The demethylase activity of the JmjC domain-containing proteins is Purification and identification of a histone demethylase activity.a, Histone.

Author: Kabei Mezilkree
Country: Jamaica
Language: English (Spanish)
Genre: History
Published (Last): 6 September 2004
Pages: 400
PDF File Size: 15.14 Mb
ePub File Size: 11.57 Mb
ISBN: 174-7-56079-639-4
Downloads: 36163
Price: Free* [*Free Regsitration Required]
Uploader: Shaktizuru

Emerging Roles of JmjC Domain-Containing Proteins.

See the description of this reaction in Rhea. In the best studied JmjC-domain proteins, the JmjC barrel has a histone demethylase catalytic activity.

Do not show this banner again. TranscriptionTranscription regulation. Manual assertion based on experiment in i. Hypoxia-Inducible Histone Lysine Demethylases: Differential intron retention in Jumonji chromatin modifier genes is implicated in reptile temperature-dependent sex determination Ira W.

Although it was originally ihstone that the JmjN and JmjC domains always co-occur and might prooteins a single functional unit within the folded protein, the JmjC domain was later found without the JmjN domain in organisms from bacteria to human [ PMID: This is also the sequence that appears in the downloadable versions of the entry.

Contributing signatures Signatures from InterPro member databases are used to construct an entry. However, one subgroup remains, the largest, in which the JmjC domain has no known biochemical function.

Histones Search for additional papers on this topic. Showing of references.

  CHRONIC RESPIRATORY QUESTIONNAIRE CRQ PDF

JmjC-domain-containing proteins and histone demethylation. — Oxford Neuroscience

Dissecting the biological roles of Kdm 3 b and Kdm 3 a lysine demethylases Ioannis Kasioulis Certain parts of this website offer the opportunity for users to post opinions, information and material including without limitation academic papers and data ‘Material’ in areas of the website.

Institutional access Recommend Jmjc-domain-cintaining to your librarian or information manager to request an extended free trial for all users at your institution.

Evidence of domain swapping within the jumonji family of transcription factors. Q95Q98 Primary citable accession number: Several domains are described mmjc-domain-containing this subsection. By posting or uploading Material you warrant and represent that: Examples of ‘Non-Financial Competing Interests’ Within the past 4 years, you have held joint grants, published or collaborated with any of the authors of the selected paper.

These proteins belong to the JmjC-domain-only subgroup and as their name suggests, the only bioinformatically recognizable domain they contain is the highly jmjc-domajn-containing JmjC domain.

Additionally, this section gives relevant information on each alternative protein isoform. Structure of factor-inhibiting hypoxia-inducible factor HIF reveals mechanism of oxidative modification of HIF-1 alpha.

You are entitled to post or upload the Material on the website and have all necessary licenses and consents to do so; the Material does not infringe any intellectual property right, including without limitation copyright, patent or trademark, or other proprietary right of any third party; the Material does not contain any defamatory, libellous, offensive, indecent or otherwise unlawful material or material which is an invasion of privacy; the Material does not contain any contaminating or destructive features or devices such as viruses, time bombs or coding designed to interrupt, destroy or limit the functionality of this website or any of this website’s user’s computer equipment or software; the Material will not hishone used to solicit or promote business or custom or present commercial activities or unlawful activity; and the Material is in compliance with all applicable laws.

  IMAGINATIA SOCIOLOGICA MILLS PDF

Your basket is currently empty.

Histone demethylation by a family of JmjC domain-containing proteins. – FPrime

Thus, we identify the JmjC domain as a novel demethylase signature motif and uncover a protein demethylation demeethylation that is conserved from yeast to human. Select a section on the left to see content. Reviewed – Annotation score: The sequence of this isoform differs from the canonical sequence as follows: Register Already registered with FPrime?

The N-termini “tails” of the histone proteins are subject to a diverse array of posttranslational modifications including methylation. The use of certain tools provided by this website is subject to additional Terms and Conditions. WBGene Expressed in 5 organ shighest expression level in multi-cellular organism. Citations Publications citing this paper.

Disclosures Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality.