Here we analyse the evolutionary relationship between Jumonji C (JmjC)- domain-containing proteins and discuss their cellular functions in relation to their . Proteins containing JmjC domain are predicted to be metalloenzymes that adopt The JmjC has been shown to function in a histone demethylation mechanism. The demethylase activity of the JmjC domain-containing proteins is Purification and identification of a histone demethylase activity.a, Histone.
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Emerging Roles of JmjC Domain-Containing Proteins.
See the description of this reaction in Rhea. In the best studied JmjC-domain proteins, the JmjC barrel has a histone demethylase catalytic activity.
Do not show this banner again. TranscriptionTranscription regulation. Manual assertion based on experiment in i. Hypoxia-Inducible Histone Lysine Demethylases: Differential intron retention in Jumonji chromatin modifier genes is implicated in reptile temperature-dependent sex determination Ira W.
Although it was originally ihstone that the JmjN and JmjC domains always co-occur and might prooteins a single functional unit within the folded protein, the JmjC domain was later found without the JmjN domain in organisms from bacteria to human [ PMID: This is also the sequence that appears in the downloadable versions of the entry.
Contributing signatures Signatures from InterPro member databases are used to construct an entry. However, one subgroup remains, the largest, in which the JmjC domain has no known biochemical function.
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JmjC-domain-containing proteins and histone demethylation. — Oxford Neuroscience
Dissecting the biological roles of Kdm 3 b and Kdm 3 a lysine demethylases Ioannis Kasioulis Certain parts of this website offer the opportunity for users to post opinions, information and material including without limitation academic papers and data ‘Material’ in areas of the website.
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Evidence of domain swapping within the jumonji family of transcription factors. Q95Q98 Primary citable accession number: Several domains are described mmjc-domain-containing this subsection. By posting or uploading Material you warrant and represent that: Examples of ‘Non-Financial Competing Interests’ Within the past 4 years, you have held joint grants, published or collaborated with any of the authors of the selected paper.
These proteins belong to the JmjC-domain-only subgroup and as their name suggests, the only bioinformatically recognizable domain they contain is the highly jmjc-domajn-containing JmjC domain.
Additionally, this section gives relevant information on each alternative protein isoform. Structure of factor-inhibiting hypoxia-inducible factor HIF reveals mechanism of oxidative modification of HIF-1 alpha.
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Histone demethylation by a family of JmjC domain-containing proteins. – FPrime
Thus, we identify the JmjC domain as a novel demethylase signature motif and uncover a protein demethylation demeethylation that is conserved from yeast to human. Select a section on the left to see content. Reviewed – Annotation score: The sequence of this isoform differs from the canonical sequence as follows: Register Already registered with FPrime?
The N-termini “tails” of the histone proteins are subject to a diverse array of posttranslational modifications including methylation. The use of certain tools provided by this website is subject to additional Terms and Conditions. WBGene Expressed in 5 organ shighest expression level in multi-cellular organism. Citations Publications citing this paper.
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