Capitulo 1 – Download as PDF File .pdf), Text File .txt) or read online. Introducao-Bioestatística – Uploaded by. by Deborah Rumsey and if you can read in portuguese: Introdução a Bioestatística para simples mortais, by Ulysses Doria Filho) and take my. . -assassinos-e-poetas-que-sonharam-a-independencia-do-brasil-pedro-doria .
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Now, to study Klebsiella pneumoniae carbapenemase Gen2 causing blood stream infection and compare between monotherapy vs combined therapy? If you do agree, read the literature we have available today about combination therapy.
Patients were included if: Moving on… The eligible patients were divided in three groups: Another thing is to realize that the study compares different sites of infection and different bacterias.
Here we have a problem, Immortal Time Bias. Combination therapy for non-believers, and believers too!
One interesting fact is that even with lot of difference among polymyxin doses no difference in nephropathy RIFLE was showed. This is gonna be a revolving theme here, so keep your eyes open! To begin with, I can do an observational trial, either retrospective or prospective, showing that doctors who drink wine 7 days a week have ulysees sex.
Combination therapy for non-believers, and believers too! – ICU Revisited
The primary outcome was infection related mortality, which was determined by the attending physician another bias here. Nothing but the whole truth. And also other strange things happened.
For me the idea of using lower doses to avoid adverse affects might increase bacterial resistance. Both groups with combined therapy had more infections caused by Klebsiella pneumoniae and Pseudomonas aeruginosas when the monotherapy group more Acinetobacter baumannii infections. From a statistical point of view, the drinker only begin to exist at day Therefore, if bioesratistica read an article showing a possible association between combined therapy and lower mortality and take this as true I can recommend you two books Statistics for Dummies, by Deborah Rumsey and if you can read in portuguese: This was a unicentric, retrospective study that from evaluated antibiotic combinations to guide therapy in patients with extensively drug-resistant gram negative bacilli XDR GNB dodia of any site.
In their majority, the most cited, are observational trials. Go hit the books then. Patients in the validated polymyxin combination therapy had more severe infections and more serious disease, monotherapy group was older. Because he had ulyssed survive our attempts to kill him as intensivists until day 5.
Meaning, if you wanna treat them, do introxuo with the right dose! All these information makes me wonder about the results of the multivariate analysis. Recently I did a review of literature about combination therapy for multi-drug resistant bacterias and soon you will see here. The median of adequate treatment for monotherapy group was ZERO! The ART trial and how lung recruitment died.
Combination therapy for non-believers, and believers too!
There it is, nebulized and intravenous are the same? Therefore, beer drinkers have lower mortality than sober patients. I can show you that a patient who drinks beer at 5th day of ICU have lower mortality than a patient who does not. The antibiotic dose was included in the multivariate model. Interestingly, was considered polymyxin use any of: I agree that is not easy to study the same bacteria, for example, Klebsiella pneumoniae carbapenemase Gen2.
Keep this in mind! Take another look at the antibiotics doses table. Why I hate tramadol but sometimes use it. Data and results Patients bioestztistica the validated polymyxin combination therapy had more severe infections and more serious disease, monotherapy group was older.
Is that honest to compare this group with others? But after a multivariate analysis the authors throw the results saying the risk of infection related mortality is 8x greater in MT group introdul 6x greater in NVCT group when compared to VCT bioestatisica.
S Army — Delta associates — Memegenerator. Is the HCAP concept a lie? Even if the patients in the VCT group were more sick, it was the only group which received adequate dose treatment. The only group which fulho polymyxin at adequate dose was the VCT group.
So, if I begin with polimyxin and just after 3 days add amikacin, this guy who recive amikacin is the same that our 5th day drunk guy.