Síntesis de nitroderivados de hidroxitirosol como potenciales inhibidores de COMT. Article in Basic & Clinical Pharmacology & Toxicology · January . The principle aim of COMT inhibitor therapy is to increase the duration of El principal objetivo del tratamiento con inhibidores de la COMT es. AMPT: α-metil-p-tirosina; COMT: catecol-O- . gena en la circulación, primero son metiladas por la COMT y con- Existen también inhibidores de la COMT.

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COMT inhibition in the treatment of Parkinson’s disease.

Cholinesterase AcetylcholinesteraseButyrylcholinesterase. For tolcapone and mg have most often proved to be the optimal doses. Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase. The effect size of genotypic moderation was quite large: Oroszi G, Goldman D December From Wikipedia, the free encyclopedia.

It is increasingly recognised that allelic variation at the COMT gene are inhibdiores relevant for emotional processing, as they seem to influence the interaction between prefrontal and limbic regions. Serine hydroxymethyltransferase 3-methyloxobutanoate hydroxymethyltransferase. The British Journal of Psychiatry.

Journal of Neural Transmission. However, there seems to be a trend for tolcapone to induce more often diarrhoea inhibidorse increase in liver transaminases compared with entacapone. The Journal of Biological Chemistry.

Two of the nitrocatechols, entacapone Their effects and significance also in the treatment of de novo patients need to be clarified. This article relies too much on references to primary sources.


The dyskinesias are managed by decreasing the daily levodopa dose in Parkinson’s disease patients with end-of-dose fluctuations.

Genes on human chromosome 22 EC 2. Temporomandibular joint dysfunction TMD does not appear to be a classic genetic disorder, however variations in the gene that codes for COMT have been suggested to be knhibidores for inheritance of a predisposition to develop TMD during life. The gene variant has been shown to affect cognitive tasks broadly related to executive functionsuch as set shifting, response inhibition, abstract thought, and the acquisition of rules or task structure.

Given the preferential role of COMT in prefrontal dopamine degradation, the ValMet polymorphism is thought to exert its effects on cognition by modulating dopamine signaling in the frontal lobes.

COMT inhibition in the treatment of Parkinson’s disease.

Please improve this by adding secondary or tertiary sources. Comparable effects on similar cognitive tasks, the frontal lobes, and the neurotransmitter dopamine have also all been linked to schizophrenia. In the brain, COMT-dependent dopamine degradation is of particular importance in brain regions with low expression of the presynaptic dopamine transporter DATsuch as the prefrontal cortex.

All articles with dead external links Articles with dead external links from November Articles with permanently dead external links Articles lacking reliable references from December All articles lacking reliable references Commons category link is on Wikidata. Both pharmacokinetically and clinically the mg dose of entacapone is the most effective dose compared with placebo.


A functional single-nucleotide inhibidorse a common normal variant of the gene for catechol-O-methyltransferase results in a valine to methionine mutation at position Val Met rs Chromosome 22 human [1].

Principles of pharmacology 3rd ed. Molecular and Cellular Biology portal. Consequently, they increase the elimination half-life of levodopa and thus prolong the availability of levodopa to the brain without significantly affecting the Cmax or tmax of levodopa.

Goetz CG May Hydroxymethyltransferase Inhibdores hydroxymethyltransferase 3-methyloxobutanoate hydroxymethyltransferase. Research conducted at the Section of Neurobiology of PsychosisInstitute of Psychiatry, King’s College London has demonstrated an effect of COMT both in patients with bipolar disorder and in their relatives, [36] [ unreliable medical source ] but these findings have not been replicated so far.

Catechol-O-methyl transferase Monoamine oxidase A B. Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase.

The best-studied is ValMet. They induce a dose-dependent inhibition of COMT activity in erythrocytes and a significant decrease in the plasma levels of 3-O-methyldopa, indicating their effectiveness as COMT inhibitors.