HYPERSEGMENTED NEUTROPHILS PDF

There are a number of conditions in which hypersegmented neutrophils may be seen, such as megaloblastic anemias (including folic acid deficiency and. BMJ Case Rep. Aug 17; pii: bcr doi: /bcr Hypersegmented neutrophils and oval macrocytes in the setting of. Hypersegmented neutrophils and reversible hyperpigmentation in vitamin B12 deficiency in Ghana. Ivy Adwowa Efiefi Ekem.

Author: Grogul Kajik
Country: Venezuela
Language: English (Spanish)
Genre: Marketing
Published (Last): 11 October 2017
Pages: 359
PDF File Size: 6.93 Mb
ePub File Size: 15.91 Mb
ISBN: 637-4-68275-343-9
Downloads: 33165
Price: Free* [*Free Regsitration Required]
Uploader: Voodoojinn

This page was last edited on nsutrophils Decemberat After diagnosis of vitamin B 12 deficiency intramuscular injections of vitamin B 12 1 mg twice a week were given over the first 3 weeks, then 1 mg every 3 months to be continued for life.

In the diagnosis of megaloblastic anaemia, a thorough history and physical examination are essential. Blood Rev ; Had a mildly enlarged liver. Case 2 was a year-old Ghanaian woman. She had no medical history of note. Recent reports show that serum vitamin B 12 value alone is insufficient for the diagnosis of vitamin B 12 deficiency.

Hematopathology

Blood smear with two hypersegmented neutrophils. Desk Reference for Hematology, Second Edition. Megaloblastic anemia in North Africa. Diagnosis of cobalamin deficiency I: She had difficulty in walking and felt numb in both feet.

Hypersegmented neutrophils and oval macrocytes in the setting of B12 deficiency and pancytopaenia.

In other projects Wikimedia Commons. In the follow-up of those patients with anaemia, a prompt increase in reticulocyte count is expected, as well as resolution of reversible symptoms and signs. Abnormal clinical and laboratory hypersegmentd for blood tests R70—R79 In case 1, the patient was initially managed as suspected haemolytic anaemia and depression with folic acid and tryptizol.

  CADALSO NOCHES LUGUBRES PDF

Her joint pains persisted however, and she also started experiencing numbness in her fingers and toes and a burning sensation in her right leg and left foot. Ivy Adwowa Efiefi Ekem. Treatment is readily available for vitamin B 12 deficiency, so early recognition is important to ensure prompt replacement therapy. Retrieved from ” https: Her serum vitamin B 12 hypeersegmented was low as expected. She was a retired educationist with adult children.

One case presented in the expected textbook manner with neurological signs, anaemia and a low serum vitamin B 12 level, whereas another presented with anaemia and hyperpigmentation, but a high serum vitamin B 12 level.

Clin Med Res ; 4: It is suggested from the literature that the high serum vitamin B 12 may have been the result of high intrinsic factor antibodies. In spite of the high serum vitamin B 12 value, the patient was anaemic, showed hypersegmented neutrophils, weakness and hyperpigmentation.

Hypersegmented neutrophils and oval macrocytes in the setting of B12 deficiency and pancytopaenia.

At the time her Hb was 9. Vitamin B 12 cobalamin and folate deficiency constitute the commonest causes of megaloblastic anaemia.

  74100 DATASHEET PDF

Open in a separate window. After diagnosis of vitamin B 12 deficiency intramuscular injections of vitamin B 12 1 mg were given twice a week over the first 3 weeks, then 1 mg every 3 months to be continued for life.

Some of the most important pointers to vitamin B 12 deficiency in Ghanaians and thus probably West Africans are hyperpigmentation, neutrophil hypersegmentation, macrocytosis and neurological signs and symptoms.

There was a problem providing the content you requested

Surgical pathology Cytopathology Autopsy Molecular pathology Forensic pathology Oral and maxillofacial pathology Gross examination Histopathology Immunohistochemistry Electron microscopy Hyperrsegmented Fluorescence in situ hybridization.

She presented with recurrent jaundice, malaise, insomnia, joint pain, numbness and dark urine for more than 84 weeks. As to whether a similar trend exists in West Africa remains to be seen. She was not pale but had hyperpigmented soles and palms, absent ankle and knee reflexes, and an arthritic left knee.

Both responded well to treatment with vitamin B Diagnosis of megaloblastic anaemias.