Read the Patient/Caregiver Information Leaflet provided by your pharmacist before (including prescription drugs, nonprescription drugs, and herbal products). Diastat. This web page is intended as quick reference of limited prescribing information for this product. This is not intended to represent a comprehensive. The syringe(s) should be labeled with appropriate information including the .. Avoid prescribing opiate cough medications in patients taking benzodiazepines.
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Flumazenil does not reverse the actions of barbiturates, opiate agonists, or tricyclic antidepressants. Clarithromycin could theoretically inhibit the CYP3A4-mediated metabolism of oxidized benzodiazepines, such as diazepam. Tobacco smoking does not affect the metabolism of the parent drug diazepam, but does accelerate the metabolism of its major active metabolite, N-desmethyldiazepam, by up to 3-fold.
In addition, worsening of depressive symptoms may occur during diazepam administration. Flumazenil does not affect the pharmacokinetics of the benzodiazepines. Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine: Moderate Systemic exposure of diazepam and its metabolite, nordiazepam, were decreased when a single 2 mg dose was administered concurrently with ombitasvir; paritaprevir; ritonavir.
Abrupt awakening can cause dysphoria, agitation, and possibly increased adverse effects. Major Concomitant use of opiate agonists with benzodiazepines may cause respiratory depression, hypotension, profound sedation, and death. If diazepam dose adjustments are made, re-adjust the dose upon completion of telaprevir treatment. Moderate The CNS-depressant effects of MAOIs can be potentiated with concomitant administration of other drugs known to cause CNS depression including buprenorphine, butorphanol, dronabinol, THC, nabilone, nalbuphine, and anxiolytics, sedatives, and hypnotics.
Diastat (diazepam) dose, indications, adverse effects, interactions from
These agents include the benzodiazepines. Moderate Clinicians should use citalopram cautiously with diazepam since co-administration with citalopram could potentially result in additive pharmacodynamic effects within the CNS.
Drugs that can cause CNS depression, if used concomitantly with olanzapine, can prescibing both the frequency and the intensity of adverse effects such as drowsiness, sedation, dizziness, and orthostatic hypotension.
Moderate Fluconazole could theoretically inhibit CYP3A4 metabolism of oxidized benzodiazepines, such as diazepam. Moderate CNS depressants, such as anxiolytics, intormation, and hypnotics, can increase the sedative effects of trihexyphenidyl.
Neonatal flaccidity has been reported in an infant whose mother was using benzodiazepines during pregnancy.
Be alert for unusual changes in moods or behaviors. Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine: Patients should discuss the use of herbal supplements with infoemation health care professional prior to consuming kava kava and should not abruptly stop taking their prescribed medications. Predictions regarding this interaction can be made based on the metabolic pathways of these drugs. The manufacturer states that diazepam has no use in psychosis and should not be used in lieu of appropriate therapy.
Moderate Co-administration of dexmedetomidine with benzodiazepines is likely to lead to an enhancement of CNS depression. Therefore, caution is advisable when combining anxiolytics, sedatives, and hypnotics or other psychoactive medications with these medications. Because of possible additive effects, advise patients about the potential for increased somnolence during concurrent use of safinamide with other sedating medications, such as benzodiazepines.
Theoretically, similar pharmacokinetic effects could be seen with diazepam. Coadminister these drugs with caution, closely monitoring the patient for adverse effects related to diazepam; a decrease in diazepam dose may be needed.
Moderate Pregabalin can potentiate the CNS-depressant action of other drugs such as benzodiazepines. infprmation
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Do not dilute diazepam injection with other solutions or drugs. Dosage must be individualized.
Sodium oxybate GHB has the potential to impair cognitive and motor skills. Patients should not abruptly stop taking their prescribed psychoactive medications. Moderate Coadministration can potentiate the CNS effects e. Moderate Monitor for withdrawal symptoms or lack of efficacy if coadministration of diazepam with enzalutamide is necessary. For tetanus, larger doses may be required. It is ready when the “Green Ready Band” in prescriibing visible.
Avoid opiate cough medications in patients taking benzodiazepines. Do not add diazepam emulsified injection to infusion sets containing PVC. Moderate Diastqt a dose reduction of diazepam as clinically appropriate, if adverse reactions occur when administered with cannabidiol.
Concomitant use of fenofibric acid with CYP2C19 substrates, such as diazepam, has not been formally studied. Moderate Phenytoin is a hepatic enzyme inducer and thus may accelerate the metabolism of several other anticonvulsants, and can theoretically add to the CNS-depressant effects of other CNS depressants, including the anxiolytics, sedatives, and hypnotics which may be used concomitantly for seizure control or as psychotropics.
Prdscribing drugs used in combination may result in elevated diazepam plasma concentrations, causing an increased risk for diazepam-related adverse events.
Cobicistat; Elvitegravir; Emtricitabine; Tenofovir Alafenamide: Benzodiazepines should be withdrawn slowly, using a gradual dosage-tapering schedule. Hydroxychloroquine can lower the seizure threshold; therefore, the activity of antiepileptic drugs may be impaired with concomitant use. Minor Diazepam, which has skeletal muscle relaxant properties, should be used cautiously in patients receiving systemic bacitracin.
Diazepam can cause physical and prescfibing dependence, and should be used with extreme caution in patients with known, suspected or a history of substance abuse.
Although the magnitude of the change in diazepam exposure does not necessitate a dosage change, patients may experience increased sedative effects due to the increase in diazepam exposure. As a result, diazepam is susceptible to interactions with drugs that inhibit these hepatic enzymes, such as diltiazem. Monitor patients for adverse effects; dose adjustment of either drug may be necessary. Less than a 2-fold increase in the midazolam AUC is not considered viastat important.