Objective: We performed a systematic review and meta-analysis of published demiological studies of developmental fluo-. ride neurotoxicity. Developmental Fluoride Neurotoxicity: Choi et al. Respond . fluoride neurotoxicity: a systematic review and meta-. analysis. Environ Health. “Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis” is a study published in Environmental Health.

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The fixed-effects model uses the Mantel—Haenszel method assuming homogeneity among the studies, whereas the random-effects model uses the DerSimonian and Laird method, incorporating both a within-study and an additive between-studies component of variance when there is between-study heterogeneity Egger et al.

J Med Pest Control. Thus, children in high-fluoride areas had significantly lower IQ scores than those who lived in low-fluoride areas.

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis

Decreased intelligence in children and exposure to fluoride and arsenic in drinking water. Using random-effects models, we estimated the standardized mean difference between exposed and reference groups across all studies. We performed meta-regression models to assess study characteristics as potential predictors of effect.

Effect of fluoride exposure on intelligence in children. Footnotes This study was neurotoxixity by internal institutional funds. On the other hand, neither can it be concluded that no risk is present.

Intelligence impact meta-anwlysis children with endemic fluorosis caused by fluoride dystematic coal burning. Future research should formally evaluate dose—response relations based on individual-level measures of exposure over time, including more precise prenatal exposure assessment and more extensive standardized measures of neurobehavioral performance, in addition to improving assessment and control of potential confounders.


Mean IQ score was significantly lower in children fluoridf lived in the high-fluoride area than that of children in the reference exposure area both areas also had arsenic exposure. This article has been cited by other articles in PMC. Chinese researchers took advantage of this fact and published their findings, though mainly in Chinese journals and according to the standards of science at the time.

The authors did not state how many reviewers performed the data extraction. Interpretation of small effect sizes in occupational and environmental neurotoxicity: Authors’ objectives To investigate the effect of increased meta-analyss exposure on delayed neurobehavioral development in children.

The authors noted that there was considerable diversity in the studies, leading to substantial unexplained heterogeneity in the results, which meant that the generalisability of the results was unclear. Average IQ of children in high-fluorosis area was lower than that in the reference area.

Nurotoxicity study with a positive association reported an SMD estimate of 0. Exclude nonstandardized testsa 23 —0. We searched records for — Citations Publications citing this paper.

Developmental fluoride neurotoxicity: a systematic review and meta-analysis.

Bias in meta-analysis detected by a simple, graphical test. I 2 residual An investigation of intelligence development of children aged 8—14 years in high-fluoride and low-iodine areas. Drinking water may contain other neurotoxicants, such as arsenic, but exclusion of studies including arsenic and iodine as co-exposures in a sensitivity analysis resulted in a lower estimate, although the difference was not significant.

From the geographic distribution of the studies, it seems unlikely that fluoride-attributed neurotoxicity could be attributable to other water contaminants. Showing of 76 extracted citations.

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis – RationalWiki

Children who lived in areas with high fluoride exposure had lower IQ scores than those who lived in low-exposure or control areas. Our literature search identified 39 studies, among which 36 In total, we identified 27 eligible epidemiological studies with high and reference exposures, end points of IQ scores, or related cognitive function measures with means and variances for the fluofide exposure groups.

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The study reviewed data on IQ test scores for children living in areas of China, Mongolia, and Iran where fluoride levels were significantly higher than those of fluoridated public water systems in the United States. Although fluoride exposure showed inverse associations with test scores, the available exposure information did not allow a formal dose—response analysis.

Journal List Environ Health Perspect v. Acknowledgments We thank V. To be included studies had to compare a high fluoride exposure group to a reference exposure group, report IQ scores or other cognitive function measures, and present a measure of the association between fluoride exposure and cognitive function measures.

In other words, and yet again, this paper documents the risks of develipmental fluoride toxicity, not water fluoridation.

Operating characteristics of a rank correlation test for publication bias. Our comprehensive review substantially extends the scope of research available for evaluation and analysis. External links Twitter Facebook Discord. Chin J Public Health.