Carcinoma nasofaríngeo. Rev Med Cos Cen ; 72 (). Language: Español References: Page: PDF: Kb. [Full text – PDF]. ABSTRACT. Since its discovery 50 years ago, Epstein-Barr virus (EBV) has been linked to the development of cancers originating from both lymphoid and epithelial cells. Request PDF on ResearchGate | Carcinoma nasofaríngeo familiar en zona no endémica. Presentación de 3 familias | Nasopharyngeal carcinoma is the.

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Furthermore, a subset of gastric adenocarcinomas and certain salivary gland carcinomas are also infected with EBV.

Check this box if you wish to receive a nasofaringeeo of your message. There are several well-described forms of EBV latency, each of which the virus uses at different stages of the viral life cycle and which are also reflected in the patterns of latency observed in various EBV-associated malignancies [2][5]. Arises in nasal cavity and paranasal sinuses only, hyperchromatic tumor cells with coarse chromatin, individual cell necrosis and necrosis of cell nests EBER – Am J Surg Pathol ; Menu di navigazione Strumenti personali Accesso non effettuato discussioni contributi registrati entra.

The virus persists in the memory B-cell pool of normal healthy individuals, and any disruption of this interaction results in virus-associated B-cell tumors.

Nel caso della neoplasia orale, prevede l’uso di un anticorpo monoclonale cetuximab che ha come bersaglio il recettore del fattore di crescita dell’epidermide EGFRda solo o in associazione alla radioterapia e a chemioterapici classici come il cisplatino e il fluorouracile [].

MRI covering the nasopharynx and cervical regions is preferred caecinoma modality to assess extent of disease and presence of intracranial extension Radiopaedia: Radiation therapy is the mainstay of treatment for all histologic types of nasopharyngeal carcinoma NCCN: Examination of 31 cell lines and review of the literaturein Oral Oncolvol. Furthermore, during its life cycle, EBV must periodically replicate to generate infectious virus for transmission to other susceptible hosts, with epithelial sites in the oropharynx cxrcinoma salivary glands appearing to be the major sites for viral replication.


Chinese Journal of Cancer.

Epstein-Barr virus and nasopharyngeal carcinoma

By using this site, you agree to the Terms of Use and Privacy Policy. Functional delivery of viral miRNAs via exosomes.

Multiple Epstein-Barr virus strains in patients with infectious mononucleosis: Journal of Translational Medicine. Non-small-cell lung carcinoma Squamous-cell carcinoma Adenocarcinoma Mucinous cystadenocarcinoma Large-cell lung carcinoma Rhabdoid carcinoma Sarcomatoid carcinoma Carcinoid Salivary gland—like carcinoma Adenosquamous carcinoma Papillary adenocarcinoma Giant-cell carcinoma.

While the EBNA1 protein has an essential role in replication and segregation of the EBV episome, it has recently been found to protect cells from apoptosis, enhance cell survival, and directly contribute to the tumorigenic phenotype [31]. LMP2A is required for the successful outgrowth of EBV-infected epithelial cells in vitro [28] and can induce anchorage-independent growth, enhance cell adhesion and cell motility, and inhibit epithelial cell differentiation [40] — [44].

Circularization occurs by homologous recombination of the TRs, resulting in fused termini of unique length—a feature that has been used as a measure of EBV clonality, on the assumption that fused TRs with an identical number of repeats denote expansions of a single infected progenitor cell [13].

Epstein-Barr virus and nasopharyngeal carcinoma

Metastatic spread may result in bone pain or organ dysfunction. Tra questi assumono particolare importanza l’ uso del tabaccosia nelle forme che ne prevedono la combustione che per masticazione, e l’ abuso nasoffaringeo alcolici carcinmoa, in grado di dare conto di circa i tre quarti di tutti i tumori orali nei paesi dove queste abitudini rappresentano la principale fonte di rischio [1] [18]. Epstein-Barr virus EBV and its associated human cancers—genetics, epigenetics, pathobiology and novel therapeutics.

Although rare, NPC accounts for about one third of childhood nasopharyngeal neoplasms.

However, epithelial infection may not be the initiating event in virus-associated carcinogenesis, as tonsils from patients with infectious mononucleosis IM and normal nasopharyngeal biopsies from individuals at high risk of developing NPC lack evidence of epithelial EBV infection [2].

The prominent lymphoid infiltrate in NPC is crcinoma to contribute to the growth and survival of the tumor cells.

Primary mucosal melanoma of nasopharynx is exceedingly rare with only a few case reports J Cancer Res Ther ; Both 3p and 9p deletions have been identified in the absence of EBV infection in low-grade dysplastic lesions and in normal nasopharyngeal epithelium from individuals at high risk of developing NPC, suggesting that these genetic events occur early in NPC pathogenesis and may predispose to subsequent EBV infection [79][82].


Allo stesso modo, non vi rientrano le forme secondarie. Variante del carcinoma squamoso che macroscopicamente presenta un aspetto tipicamente esofitico-papillare, moderata tendenza delle cellule neoplastiche al superamento dello strato basale e prognosi favorevole, anche se con spiccata tendenza alla recidiva. L’efficacia di questi approcci ai fini nasofaringe prevenzione carcinoka sviluppo di una forma maligna ansofaringeo comunque essere dubbia [75].

Nasopharynx cancer – Wikipedia

Per il recupero di una corretta funzione fonatoriadella deglutizione e respirazioneviene inoltre utilizzato il supporto dello specialista in logopedia []. National Center for Biotechnology InformationU. In other projects Wikimedia Commons. Retrieved carxinoma ” https: Uterine cervical lymphoepithelial-like carcinoma.

Nasopharynx cancer

Le informazioni riportate non sono consigli medici e potrebbero non essere accurate. This results in low-grade, preinvasive lesions that, after additional genetic and epigenetic events, become susceptible to stable EBV infection. High frequency of chromosome 3p deletion in histologically normal nasopharyngeal epithelia from Southern Chinese.

Carcinomas with similar features to undifferentiated NPC have been described at other sites including the thymus, tonsils, lungs, stomach, skin, or uterine cervix and are often referred to as undifferentiated carcinomas of nasopharyngeal type UCNT or lymphoepitheliomas. Questo potrebbe essere confermato dalla correlazione riscontrata tra livello di sostanze immunosoppressive e progressione neoplastica nei nasofaingeo malati [52].

Disease definition Nasopharyngeal carcinoma NPC is a tumor arising from the epithelial cells that cover carcnoma surface and line the nasopharynx.

L’associazione tra scadente igiene orale o presenza di stimoli irritativi protesi incongrue o lesioni cariose e patologia parodontale e il cancro orale viene frequentemente osservata clinicamente [53]. Nasopharyngeal carcinoma originates from the nasopharyngeal mucosa showing histologic or immunophenotypic evidence of squamous differentiation WHO classification of nasopharyngeal carcinoma El-Naggar: