Mar 1, Aquasomes are spherical 60– nm particles used for drug and antigen delivery. Aquasomes discovery comprises a principle from. Sep 6, Aquasomes are spherical 60– nm particles used for drug and antigen delivery. Aquasomes discovery comprises a principle from. Mar 13, PDF | Aquasomes are three-layered ceramic core based carbohydrate coated nanoparticle delivery systems with bioactive molecules adsorbed.
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Their large sized and active surfaces enable them to be loaded with water insoluble drugs through non covalent processes.
Calcium phosphate is the core of interest, owing to its natural presence in the body. Aquasomes are one of the most recently developed delivery systems that are finding a niche as peptide and protein carriers. Aquasome deliver their content through specific targeting, molecular sheiling and slow sustained release process.
Three types of core materials are mainly used for producing aquasomes: The solid core provides the structural stability, while the carbohydrate coating protects against dehydration and stabilizes the biochemically active molecules. Aquasomes discovery comprises a principle from microbiology, food chemistry, biophysics and many discoveries including solid phase synthesis, supramolecular chemistry, molecular shape change and self assembly.
Aquasomes are nanoparticulate carrier system but instead of being simple nanoparticles these arse three layered self assembled structures, comprised of a solid phase nanocrystalline core coated with oligomeric film to which biochemically active molecules are adsorbed with or without modification. They comprise aquasojes central solid nanocrystalline core coated with polyhydroxy oligomers onto which biochemically active molecules are adsorbed.
Nanobiopharmaceutics involves delivery of biopharmaceutical product through different biomaterials like multifunctional nanoparticles, quantum dots, aquasomes, superparamagnetic iron oxide crystals, and liposomes dendrimers.
Department of Pharmacology, K. Their intended route of administration is parenteral and with advancement of research in this field, other routes might be contemplated.
This article discusses the problems faced in the delivery of clinically important peptides and presents aquasomes as a reliable approach to troubleshoot them.
This article reviews the principles of self assembly, the challenges of maintaining both the conformational integrity and biochemical activity of immobilized surface pairs, and the convergence of these principles into a single functional composition. Aquasomes are spherical 60— nm particles used for drug and antigen delivery.
Aquasomes: a promising carrier for peptides and protein delivery.
It is widely used for the preparation of implants for drug delivery. This property of maintaining the conformational integrity of bioactive molecules has led to the proposal that aquasomes have potential as a carrier system for delivery of peptide, protein, hormones, antigens and genes to specific sites.
These are nanoparticulate carrier systems with three-layered self-assembled structures. The brushite is unstable and converts to hydroxyapatite upon prolong storage.
delievry This property of maintaining the conformational integrity of bioactive molecules has led to the proposal that aquasomes have potential as a carrier system for delivery of peptide-based pharmaceuticals. Aquasome technology represents a patform system for conformational integrality and biochemical stability of bioactives. Nanotechnology has emerged fields of biomedical research in the last few decades the presents context is an attempt to present the brief information about nanobiotechnological applications.
The solid core provides the structural stability, while the carbohydrate coating protects against dehydration and stabilizes the biochemically active molecules.
The delivery system has been successfully utilized for the aquawomes of insulin, hemoglobin, and various antigens. Oral delivery of enzymes like serratiopeptidase has also been achieved. Hydroxyapatite seems, therefore, a better core for the preparation of aquasomes. Article Information Sr No: