Hemolíticas. Keywords: Autoimmune hemolytic anemia, cold agglutinin disease, autoantibodies, treatment. Palabras clave: Anemia hemolitica autoinmune. Request PDF on ResearchGate | Protocolo diagnóstico de las anemias hemolíticas | The hemolytic anemias diagnosis remains a clinical challenge. Once a. Download Citation on ResearchGate | On Nov 1, , M. J. García Rodríguez and others published Protocolo diagnóstico de las anemias hemolíticas.

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J Vet Intern Med 21, Vet Clin Pathol 20, Mortality in sickle cell disease.

Roberto Ferreira Pinto Machado. Hematol Oncol Clin North Am. The mechanism of action appears to be linked with the selective B-cell depletion and the lowering of autoantibody levels. Severity of pulmonary hypertension during vaso-occlusive pain crisis and exercise in patients with sickle cell disease.

Pyruvate kinase deficiency causing hemolytic anemia with secondary hemo-chromatosis in Cairn terrier. Vet Clin Pathol 39, Pulmonary hypertension in sickle cell disease: Breed-specific hereditary diseases and genetic screening.

Nevertheless, a transfusion was deemed so desperately needed that blood from a “universal donor” was given. Vet J This case study reports the clinical and laboratory findings in a West Highland White Terrier WHWT dog with a life-long history of weakness and exercise intolerance from Brazil. Mol Med 16, In addition, normoblasts are released into the circulation. J Pediatr The approach should be fast so that we can offer a better survival for these patients.


Blood proteins C and S in sickle cell disease. For yet unexplained reasons, all PK-deficient dogs develop a progressive myelofibrosis and then osteosclerosis, as seen in this case, though PK-deficient cats and humans do not experience osteoclerosis. Many animals with hemolytic anemia are initially misdiagnosed and treated for infectious diseases e.

REDACCIÓN MÉDICA: El Clínico investigará la mutación que causa las anemias hemolíticas

SCS Quadra 1, Bl. Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, anemia mortality in sickle cell disease. However, no spherocytes, Heinz bodies, poikilocytes or infectious agents were detected, and the direct Coomb’s test was negative for IgG antibodies on RBCs.

Sickle cell chronic lung disease: Changes in coagulation and fibrinolysis in patients with sickle cell disease compared with healthy black controls. Pulmonary hemolitcias and sickle hemoglobinopathy. This case report describes the clinical course, laboratory alterations, molecular diagnosis, and management of the first PK-deficient Brazilian WHWT dog, suggesting the potential worldwide distribution of anemizs disorder and that it possibly goes by under-diagnosed.

However, the anemia did not improve, and the animal’s overall condition deteriorated to the point where the owners elected euthanasia. Dogs with PK deficiency often have normal white blood cell counts. In order to prevent the further spread of this and other hereditary diseases, it is essential to recognize not only the affected animals, but also the carriers that can transmit the anemiass allele to their offspring.


Hereditary spherocytosis, thrombocytosis, and chronic pulmonary emboli: Diastolic dysfunction is an independent risk factor for death in patients hemoliyicas sickle cell disease. Based upon the clinical signs and anemia a transfusion was deemed necessary.

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Nocturnal hypoxaemia and central-nervous-system events in sickle-cell disease. Pulmonary hypertension as a risk factor for death in patients with sickle cell disease.

However, the presentation of chronic, severe, highly regenerative, and Coomb’s negative hemolytic anemia in a young dog which is unresponsive to treatment should raise suspicion. Indeed, this likely explains why most PK-deficient dogs hemoliticaas cope so well, despite a persistently severe anemia Chapman and GigerGiger and NobleGiger